Manufacturing consensus in a diverse field of scholarly opinions: A comment on Bushman, Gollwitzer, and Cruz (2015).

We appreciate the efforts of Bushman and Cruz to provide new data describing parents’ and professionals’ opinions regarding effects of media violence. Unfortunately, we feel it is necessary to call attention to apparent errors and inaccuracies in the way those data are interpreted and represented in their article. The article overstates the extent to which there is agreement that media violence has meaningful negative societal effects and misrepresents the relevance of the study to an understanding of the effects of media violence on societal violence. In contrast, we call for a climate of research on media violence that better recognizes the diversity of findings and conclusions in an active and growing research agenda and eschews unwarranted insinuations about effects on criminal violence from research focused on aggression-related measures not assessing violent crime

Nonlinear analysis of a simple model of temperature evolution in a satellite

We analyse a simple model of the heat transfer to and from a small satellite orbiting round a solar system planet. Our approach considers the satellite isothermal, with external heat input from the environment and from internal energy dissipation, and output to the environment as black-body radiation. The resulting nonlinear ordinary differential equation for the satellite's temperature is analysed by qualitative, perturbation and numerical methods, which show that the temperature approaches a periodic pattern (attracting limit cycle). This approach can occur in two ways, according to the values of the parameters: (i) a slow decay towards the limit cycle over a time longer than the period, or (ii) a fast decay towards the limit cycle over a time shorter than the period. In the first case, an exactly soluble average equation is valid. We discuss the consequences of our model for the thermal stability of satellites.Comment: 13 pages, 4 figures (5 EPS files

Lattice-Boltzmann Method for Geophysical Plastic Flows

We explore possible applications of the Lattice-Boltzmann Method for the simulation of geophysical flows. This fluid solver, while successful in other fields, is still rarely used for geotechnical applications. We show how the standard method can be modified to represent free-surface realization of mudflows, debris flows, and in general any plastic flow, through the implementation of a Bingham constitutive model. The chapter is completed by an example of a full-scale simulation of a plastic fluid flowing down an inclined channel and depositing on a flat surface. An application is given, where the fluid interacts with a vertical obstacle in the channel.Comment: in W. Wu, R.I. Borja (Edts.) Recent advances in modelling landslides and debris flow, Springer Series in Geomechanics and Geoengineering (2014), ISBN 978-3-319-11052-3, pp. 131-14

Nonlinear analysis of spacecraft thermal models

We study the differential equations of lumped-parameter models of spacecraft thermal control. Firstly, we consider a satellite model consisting of two isothermal parts (nodes): an outer part that absorbs heat from the environment as radiation of various types and radiates heat as a black-body, and an inner part that just dissipates heat at a constant rate. The resulting system of two nonlinear ordinary differential equations for the satellite's temperatures is analyzed with various methods, which prove that the temperatures approach a steady state if the heat input is constant, whereas they approach a limit cycle if it varies periodically. Secondly, we generalize those methods to study a many-node thermal model of a spacecraft: this model also has a stable steady state under constant heat inputs that becomes a limit cycle if the inputs vary periodically. Finally, we propose new numerical analyses of spacecraft thermal models based on our results, to complement the analyses normally carried out with commercial software packages.Comment: 29 pages, 4 figure

A Quantum-Bayesian Route to Quantum-State Space

In the quantum-Bayesian approach to quantum foundations, a quantum state is viewed as an expression of an agent's personalist Bayesian degrees of belief, or probabilities, concerning the results of measurements. These probabilities obey the usual probability rules as required by Dutch-book coherence, but quantum mechanics imposes additional constraints upon them. In this paper, we explore the question of deriving the structure of quantum-state space from a set of assumptions in the spirit of quantum Bayesianism. The starting point is the representation of quantum states induced by a symmetric informationally complete measurement or SIC. In this representation, the Born rule takes the form of a particularly simple modification of the law of total probability. We show how to derive key features of quantum-state space from (i) the requirement that the Born rule arises as a simple modification of the law of total probability and (ii) a limited number of additional assumptions of a strong Bayesian flavor.Comment: 7 pages, 1 figure, to appear in Foundations of Physics; this is a condensation of the argument in arXiv:0906.2187v1 [quant-ph], with special attention paid to making all assumptions explici

Detection of Supernova Neutrinos by Neutrino-Proton Elastic Scattering

We propose that neutrino-proton elastic scattering, $\nu + p \to \nu + p$, can be used for the detection of supernova neutrinos in scintillator detectors. Though the proton recoil kinetic energy spectrum is soft, with $T_p \simeq 2 E_\nu^2/M_p$, and the scintillation light output from slow, heavily ionizing protons is quenched, the yield above a realistic threshold is nearly as large as that from $\bar{\nu}_e + p \to e^+ + n$. In addition, the measured proton spectrum is related to the incident neutrino spectrum, which solves a long-standing problem of how to separately measure the total energy and temperature of $\nu_\mu$, $\nu_\tau$, $\bar{\nu}_\mu$, and $\bar{\nu}_\tau$. The ability to detect this signal would give detectors like KamLAND and Borexino a crucial and unique role in the quest to detect supernova neutrinos.Comment: 10 pages, 9 figures, revtex

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

Immunogenetics and cellular immunology of bacterial infectious disease

Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development

Aims Vertebrate heart development requires the complex morphogenesis of a linear tube to form the mature organ, a process essential for correct cardiac form and function, requiring coordination of embryonic laterality, cardiac growth, and regionalized cellular changes. While previous studies have demonstrated broad requirements for extracellular matrix (ECM) components in cardiac morphogenesis, we hypothesized that ECM regionalization may fine tune cardiac shape during heart development. Methods and results Using live in vivo light sheet imaging of zebrafish embryos, we describe a left-sided expansion of the ECM between the myocardium and endocardium prior to the onset of heart looping and chamber ballooning. Analysis using an ECM sensor revealed the cardiac ECM is further regionalized along the atrioventricular axis. Spatial transcriptomic analysis of gene expression in the heart tube identified candidate genes that may drive ECM expansion. This approach identified regionalized expression of hapln1a, encoding an ECM cross-linking protein. Validation of transcriptomic data by in situ hybridization confirmed regionalized hapln1a expression in the heart, with highest levels of expression in the future atrium and on the left side of the tube, overlapping with the observed ECM expansion. Analysis of CRISPR-Cas9-generated hapln1a mutants revealed a reduction in atrial size and reduced chamber ballooning. Loss-of-function analysis demonstrated that ECM expansion is dependent upon Hapln1a, together supporting a role for Hapln1a in regionalized ECM modulation and cardiac morphogenesis. Analysis of hapln1a expression in zebrafish mutants with randomized or absent embryonic left–right asymmetry revealed that laterality cues position hapln1a-expressing cells asymmetrically in the left side of the heart tube. Conclusion We identify a regionalized ECM expansion in the heart tube which promotes correct heart development, and propose a novel model whereby embryonic laterality cues orient the axis of ECM asymmetry in the heart, suggesting these two pathways interact to promote robust cardiac morphogenesis